The interactions between Cd and Hg with these enzymes were used by MIB: Metal Ion-Binding site prediction and docking server (). ![]() The structure of the enzymes was obtained from the RCSB Protein Data Bank () with the following code, GS (PDB ID: 1RZV) and PFK (PDB ID: 4WLO). For this reason, this research was carried out using in silico. ![]() There are not many studies that explain the interactions between Cd and Hg on GS and PFK enzymes. by changing the structure and enzymatic activity of proteins which can cause toxic effects on enzymes involved therein including glycogen synthase (GS), which can cause glycogen content depletion and has potential to limit the glycolysis process in liver and muscles by decreasing the phosphofructokinase (PFK) enzyme activity. The long-term exposure of Cd and Hg can affect enzymes involved in carbohydrate metabolism, on the process of glycolysis and glycogenesis. ![]() Cadmium (Cd) and Mercury (Hg) is a heavy metal with high cytotoxicity, implicated as causes of chronic inflammation, oxidative stress, obesity, hyperglycemia, and even diabetes.
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